COL4A4 and ANTXR2

Number of citations of the paper that reports this interaction (PubMedID 11683410)
124

Data Source:
HPRD (in vitro)

		COL4A4	ANTXR2
Description		collagen type IV alpha 4 chain	ANTXR cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Reproductive Process Toxin Transport
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome	Infantile systemic hyalinosis and juvenile hyaline fibromatosis
GWAS		Birth weight ( 31043758) Body mass index ( 28270201 25673413) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Hand grip strength ( 29691431) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myopia ( 27182965) Neutrophil percentage of white cells ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI	10 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 DDX10 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2
Entrez ID		1286	118429
HPRD ID		00360	07452
Ensembl ID		ENSG00000081052	ENSG00000163297
Uniprot IDs		P53420	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5NB1	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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