COL4A3 and ANTXR2

Number of citations of the paper that reports this interaction (PubMedID 11683410)
124

Data Source:
HPRD (in vivo)

		COL4A3	ANTXR2
Description		collagen type IV alpha 3 chain	ANTXR cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Blood Circulation Negative Regulation Of Cell Proliferation Response To Glucose Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation	Reproductive Process Toxin Transport
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome	Infantile systemic hyalinosis and juvenile hyaline fibromatosis
GWAS		Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 31798171 29760442) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Resting heart rate ( 27798624)	Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Hand grip strength ( 29691431) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myopia ( 27182965) Neutrophil percentage of white cells ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A	10 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 DDX10 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2
Entrez ID		1285	118429
HPRD ID		00354	07452
Ensembl ID		ENSG00000169031	ENSG00000163297
Uniprot IDs		Q01955	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5NB0	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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