COL4A2 and COL4A1

Number of citations of the paper that reports this interaction (PubMedID 12011424)
31

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		COL4A2	COL4A1
Description		collagen type IV alpha 2 chain	collagen type IV alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Transcription, DNA-templated Aging Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus	Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Extracellular Matrix Organization Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Blood urea nitrogen levels ( 31152163) Coronary artery calcification ( 22144573) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878) Glomerular filtration rate ( 29403010) Intake of sweets ( 31005972) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol ( 30275531) Maximum retinal arteriolar tortuosity ( 31597446) Middle temporal gyrus volume ( 31530798) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage ( 31430377) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Retinal arteriolar tortuosity ( 31597446) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Total cholesterol levels ( 30275531) White matter hyperintensity burden ( 25663218)	Age-related nuclear cataracts ( 24951543) Arterial stiffness ( 20031579) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Coronary artery disease ( 29212778 24262325 30104761 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Intraocular pressure ( 29785010 31959993) Lateral ventricle volume ( 31530798) Metabolite levels ( 23823483) Monocyte count ( 27863252) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Peripheral artery disease ( 31285632) Pulse pressure ( 30578418) Stroke ( 30383316 29531354) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL	27 interacting genes: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1
Entrez ID		1284	1282
HPRD ID		00355	00359
Ensembl ID		ENSG00000134871	ENSG00000187498
Uniprot IDs		A0A024RDW8 P08572	A5PKV2 P02462
PDB IDs		1LI1 5NAX 5NB2 6MPX	1LI1 5NAX 5NAY 6MPX
Enriched GO Terms of Interacting Partners?
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