PRXL2B and TNFSF11

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PRXL2B	TNFSF11
Description		peroxiredoxin like 2B	TNF superfamily member 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Myelin Sheath Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Antioxidant Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Prostaglandin-F Synthase Activity	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Oxidation-reduction Process Cellular Oxidant Detoxification	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Tooth Eruption Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Actin Binding Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Lenalidomide Denosumab Thiocolchicoside
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS			Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740 23437003) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 29403010) Vitiligo ( 27723757)
Interacting Genes		2 interacting genes: PDPK1 TNFSF11	30 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1
Entrez ID		127281	8600
HPRD ID		14513	04031
Ensembl ID		ENSG00000157870	ENSG00000120659
Uniprot IDs		A0A0A0MRV4 A0A0A0MT35 A0A2P0CTB1 A0A2P0CU24 Q8TBF2	O14788 Q54A98 Q5T9Y4
PDB IDs			3URF 5BNQ
Enriched GO Terms of Interacting Partners?
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