TNFSF11 and MED24

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TNFSF11	MED24
Description		TNF superfamily member 11	mediator complex subunit 24
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Tooth Eruption Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Actin Binding Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development	Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Lenalidomide Denosumab Thiocolchicoside
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740 23437003) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 29403010) Vitiligo ( 27723757)	Asthma ( 31619474) Bipolar disorder ( 31043756) Estimated glomerular filtration rate ( 31152163) Mitochondrial DNA copy number ( 30704525) Neutrophil count ( 25096241 29403010) Pancreatic ductal adenocarcinoma ( 30541042) Pursuit maintenance gain ( 29064472) White blood cell count ( 22037903 20139978 21738480 28158719)
Interacting Genes		30 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1	14 interacting genes: APP AR CTDP1 ESR1 ESR2 GSK3B HNF4A MED9 PPARA PPARG RPS6KA6 RXRA SREBF1 TNFSF11
Entrez ID		8600	9862
HPRD ID		04031	06107
Ensembl ID		ENSG00000120659	ENSG00000008838
Uniprot IDs		O14788 Q54A98 Q5T9Y4	F5GY88 O75448
PDB IDs		3URF 5BNQ
Enriched GO Terms of Interacting Partners?
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