CLTC and DNAJC6

Number of citations of the paper that reports this interaction (PubMedID 11470803)
21

Data Source:
HPRD (in vitro)

		CLTC	DNAJC6
Description		clathrin heavy chain	DnaJ heat shock protein family (Hsp40) member C6
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Cytoplasm Cytosol Postsynaptic Density Vesicle Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Protein Tyrosine Phosphatase Activity SH3 Domain Binding Clathrin Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Transferrin Transport Low-density Lipoprotein Particle Clearance Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Mitotic Spindle Organization Membrane Organization Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Receptor-mediated Endocytosis Synaptic Vesicle Uncoating Peptidyl-tyrosine Dephosphorylation Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Anticoagulant levels ( 22216198) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		56 interacting genes: AMPH AP1B1 AP1G1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS1 SCYL2 SMAP1 SNX5 SNX9 SRC STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	3 interacting genes: AP2A2 BAG2 CLTC
Entrez ID		1213	9829
HPRD ID		00350	16326
Ensembl ID		ENSG00000141367	ENSG00000116675
Uniprot IDs		A0A087WVQ6 Q00610	O75061
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP
Enriched GO Terms of Interacting Partners?
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