AGAP1 and GUCY1A1

Number of citations of the paper that reports this interaction (PubMedID 15381706)
9

Data Source:
HPRD (in vivo, two hybrid)

		AGAP1	GUCY1A1
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	guanylate cyclase 1 soluble subunit alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Guanylate Cyclase Complex, Soluble Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding Metal Ion Binding	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Signaling Receptor Activity
	Biological Process	Protein Transport Positive Regulation Of GTPase Activity	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Regulation Of Blood Pressure Positive Regulation Of Nitric Oxide Mediated Signal Transduction Modulation By Symbiont Of Defense-related Host Nitric Oxide Production Relaxation Of Vascular Smooth Muscle Retrograde Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission
Pathways			Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs
Diseases
GWAS		Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		12 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA SMN1 SRC TK1	4 interacting genes: AGAP1 IKBKG MAPK8 STUB1
Entrez ID		116987	2982
HPRD ID		16359	00768
Ensembl ID		ENSG00000157985	ENSG00000164116
Uniprot IDs		B2RZG9 Q9UPQ3 X5D293	B3KU69 Q02108
PDB IDs			3UVJ 4NI2 6JT0 6JT1 6JT2
Enriched GO Terms of Interacting Partners?
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