AGAP1 and GRB7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		AGAP1	GRB7
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	growth factor receptor bound protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection
	Molecular Function	GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding Metal Ion Binding	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Protein Transport Positive Regulation Of GTPase Activity	Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly ERBB2 Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Leukocyte Migration
Pathways			GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling
Drugs
Diseases
GWAS		Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Asthma ( 31619474 28461288) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 20228799)
Interacting Genes		12 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA SMN1 SRC TK1	42 interacting genes: A1BG AGAP1 ATP5F1B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16 ZNHIT1
Entrez ID		116987	2886
HPRD ID		16359	03311
Ensembl ID		ENSG00000157985	ENSG00000141738
Uniprot IDs		B2RZG9 Q9UPQ3 X5D293	A0A0S2Z4F6 Q14451
PDB IDs			1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q
Enriched GO Terms of Interacting Partners?
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