CISH and IL3RA

Number of citations of the paper that reports this interaction (PubMedID 7796808)
123

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CISH	IL3RA
Description		cytokine inducible SH2 containing protein	interleukin 3 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Cytokine Receptor Activity Interleukin-3 Receptor Activity Cytokine Binding
	Biological Process	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs			Sargramostim
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025)	Schizophrenia ( 17522711)
Interacting Genes		18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	15 interacting genes: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2
Entrez ID		1154	3563
HPRD ID		03897	02392
Ensembl ID		ENSG00000114737	ENSG00000185291
Uniprot IDs		Q9NSE2	P26951
PDB IDs			4JZJ 5UV8 5UWC
Enriched GO Terms of Interacting Partners?
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