SLAMF6 and SH2D1A

Number of citations of the paper that reports this interaction (PubMedID 11489943)
68

Data Source:
HPRD (in vitro, in vivo)

		SLAMF6	SH2D1A
Description		SLAM family member 6	SH2 domain containing 1A
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Protein Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response T-helper 17 Cell Lineage Commitment	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Blood protein levels ( 30072576 29875488) Graves' disease ( 23612905) Multiple sclerosis ( 24076602)
Interacting Genes		4 interacting genes: PTPN11 PTPN6 SH2D1A ZAP70	26 interacting genes: ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB3 FYB1 FYN GRB2 LCK LETMD1 LHX4 LY9 MAPK11 MAPK14 NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		114836	4068
HPRD ID		05920	02390
Ensembl ID		ENSG00000162739	ENSG00000183918
Uniprot IDs		B4E1U5 Q96DU3	O60880
PDB IDs		2IF7	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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