TRIM9 and MUL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM9	MUL1
Description		tripartite motif containing 9	mitochondrial E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Cell Junction Dendrite Presynaptic Cytosol	Mitochondrion Peroxisome Membrane Axon Integral Component Of Mitochondrial Outer Membrane Neuronal Cell Body
	Molecular Function	SNARE Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Synaptic Vesicle Exocytosis Protein Ubiquitination Negative Regulation Of SNARE Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis	Mitochondrial Fission Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		28 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL EXOC1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID PCGF3 RNF166 RPL4P5 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 VASP	30 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 MAP3K7 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W ULK1
Entrez ID		114088	79594
HPRD ID		05947	07799
Ensembl ID		ENSG00000100505	ENSG00000090432
Uniprot IDs		Q9C026	A1PUM0 Q969V5
PDB IDs		2DB8	6K2K
Enriched GO Terms of Interacting Partners?
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