EXOSC8 and DUSP23

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		EXOSC8	DUSP23
Description		exosome component 8	dual specificity phosphatase 23
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Exoribonuclease Activity Protein Binding AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process	Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs			4-Nitrophenyl Phosphate
Diseases
GWAS			Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Interacting Genes		49 interacting genes: AEN ATF2 CAB39L COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EEF1DP3 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MAPK8IP1 MKRN1 MORN4 MPHOSPH6 MPP6 MTREX N4BP2L2 OTUD4 PDCD1LG2 RASSF1 REL RERG RPP14 RXRB SNRPB SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36	24 interacting genes: ASB13 CCDC186 CEP126 DBI DBN1 DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRPL20 MTFR1 NIF3L1 PRDX4 RPL8 RUFY2 SHC1 SMPD1 TMOD3 TUBA1A ZNF746
Entrez ID		11340	54935
HPRD ID		09351	07908
Ensembl ID		ENSG00000120699	ENSG00000158716
Uniprot IDs		Q96B26	A0A140VJI5 Q9BVJ7
PDB IDs		2NN6 6D6Q 6D6R 6H25	2IMG 4ERC
Enriched GO Terms of Interacting Partners?
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