DACH1 and NCOR1

Number of citations of the paper that reports this interaction (PubMedID 14525983)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		DACH1	NCOR1
Description		dachshund family transcription factor 1	nuclear receptor corepressor 1
Image
GO Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Cytosol Membrane Sin3 Complex Transcriptional Repressor Complex Mitotic Spindle
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of Transcription, DNA-templated Respiratory Gaseous Exchange Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Transcription, DNA-templated Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription By RNA Polymerase II Circadian Rhythm Regulation Of Lipid Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways			Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood urea nitrogen levels ( 31152163 29403010) Chronic kidney disease ( 20383146) Chronotype ( 30696823) Cleft palate ( 30452639) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Longevity ( 20834067) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Obsessive-compulsive disorder ( 22889921) Plateletcrit ( 27863252) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Restless legs syndrome ( 29029846) Serum uric acid levels ( 30993211) Stroke ( 29531354) Total cholesterol levels ( 30498476) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Verbal declarative memory ( 25648963) White blood cell count ( 31217584)	C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560)
Interacting Genes		31 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC MYCBP2 NAGK NCOR1 NF2 NFIC PPIG RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I ZCCHC10	86 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB7A ZMYND11
Entrez ID		1602	9611
HPRD ID		16031	02911
Ensembl ID		ENSG00000276644	ENSG00000141027
Uniprot IDs		Q9UI36	A0A024RD47 O75376 Q6PGR4
PDB IDs		1L8R	2EQR 3H52 3KMZ 3N00 4MDD 4WVD
Enriched GO Terms of Interacting Partners?
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