PARK7 and NDUFA4

Number of citations of the paper that reports this interaction (PubMedID 19822128)
55

Data Source:
BioGRID (pull down)

		PARK7	NDUFA4
Description		Parkinsonism associated deglycase	NDUFA4 mitochondrial complex associated
Image
GO Annotations	Cellular Component	Chromatin Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction PML Body Axon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Respiratory Chain Complex IV
	Molecular Function	Core Promoter Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Transcription Factor Binding Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Kinase Binding Cytokine Binding Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Cadherin Binding Mercury Ion Binding Androgen Receptor Binding Peroxiredoxin Activity Repressing Transcription Factor Binding Scaffold Protein Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding	Cytochrome-c Oxidase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Negative Regulation Of Protein Kinase Activity Proteolysis Protein Deglycosylation Autophagy Inflammatory Response Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Histone Modification Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Lactate Biosynthetic Process Insulin Secretion Positive Regulation Of Protein Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Sumoylation Positive Regulation Of NAD(P)H Oxidase Activity Cellular Response To Oxidative Stress Cellular Response To Glyoxal Peptidyl-cysteine Deglycation Peptidyl-arginine Deglycation Peptidyl-lysine Deglycation Protein Deglycation, Glyoxal Removal Protein Deglycation, Methylglyoxal Removal Glutathione Deglycation Glucose Homeostasis Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of TRAIL Receptor Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Membrane Hyperpolarization Negative Regulation Of Cell Death Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Oxidant Detoxification Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Protein Acetylation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Positive Regulation Of L-dopa Decarboxylase Activity Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Androgen Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport
Pathways		SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs		Copper	NADH
Diseases		Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Ulcerative colitis ( 28067908 21297633)	Dental caries (decayed, missing and filled teeth) ( 31533690) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Heschl's gyrus morphology ( 25130324) Lung cancer ( 28604730) Mercury levels ( 26025379) Metabolite levels ( 23823483)
Interacting Genes		24 interacting genes: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 NDUFA4 PIAS2 PINK1 PPP2R1A PPP2R1B PTEN SOD1 SUMO1 UBA2 UBE2I	3 interacting genes: APP FBLN5 PARK7
Entrez ID		11315	4697
HPRD ID		03961	04831
Ensembl ID		ENSG00000116288	ENSG00000189043
Uniprot IDs		Q99497 V9HWC2	A0A024R9Z0 O00483
PDB IDs		1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z	5Z62
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?