PACSIN2 and PACSIN1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		PACSIN2	PACSIN1
Description		protein kinase C and casein kinase substrate in neurons 2	protein kinase C and casein kinase substrate in neurons 1
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Nuclear Speck Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone
	Molecular Function	Transporter Activity Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Membrane Organization Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways		Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Mean platelet volume ( 27863252) Platelet count ( 27863252) Platelet distribution width ( 27863252) Prostate cancer (SNP x SNP interaction) ( 22219177)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Inflammatory bowel disease ( 27569725) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		12 interacting genes: DNM1 FASLG MEOX2 PACSIN1 PACSIN3 POT1 SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	24 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		11252	29993
HPRD ID		05390	05936
Ensembl ID		ENSG00000100266	ENSG00000124507
Uniprot IDs		Q6FIA3 Q9UNF0	Q5TZC3 Q9BY11
PDB IDs		3ABH 3ACO 3HAJ 3Q0K	3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?
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