PACSIN1 and RTKN2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		PACSIN1	RTKN2
Description		protein kinase C and casein kinase substrate in neurons 1	rhotekin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Signal Transduction Positive Regulation Of Cell Proliferation Hemopoiesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Inflammatory bowel disease ( 27569725) Waist-to-hip ratio adjusted for BMI ( 28552196)	Diastolic blood pressure ( 19430483) Hypothyroidism ( 27182965) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 30423114 23028356 24390342) Systemic lupus erythematosus ( 23273568)
Interacting Genes		24 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	2 interacting genes: BRCA1 PACSIN1
Entrez ID		29993	219790
HPRD ID		05936	17863
Ensembl ID		ENSG00000124507	ENSG00000182010
Uniprot IDs		Q5TZC3 Q9BY11	Q8IZC4
PDB IDs		3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?
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