ADAP1 and PIK3CA

Number of citations of the paper that reports this interaction (PubMedID 12893243)
4

Data Source:
BioGRID (pull down, enzymatic study)

		ADAP1	PIK3CA
Description		ArfGAP with dual PH domains 1	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Cell Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane Lamellipodium
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding Phosphatidylinositol Bisphosphate Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of GTPase Activity	Angiogenesis Liver Development Vasculature Development Glucose Metabolic Process Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axon Guidance Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Regulation Of Multicellular Organism Growth Anoikis Regulation Of Cellular Respiration Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Hypomethylation Of CpG Island Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Contraction Adipose Tissue Development Cellular Response To Glucose Stimulus Energy Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Genetic Imprinting Negative Regulation Of Anoikis
Pathways		Nuclear signaling by ERBB4	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Extra-nuclear estrogen signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants
Drugs			ATP Caffeine XL765 (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE Pilaralisib Copanlisib
Diseases			Ovarian cancer
GWAS			Mean corpuscular hemoglobin ( 29403010)
Interacting Genes		23 interacting genes: ANP32A AP3B2 CSNK1A1 DVL3 GADD45A GOLGA2 GSK3B NCL PIK3CA PRKCA PRKCE PRKCI PRKCZ PRKD1 PSME3 PURA RANBP9 RPS9 SDCBP2 SF3A3 SRSF2 SUB1 SUPV3L1	64 interacting genes: ADAP1 AKT1 AMBP APLP2 APPL1 ARAF ATP5IF1 ATR BEX1 BEX2 CCND2 CSF1R CYTH2 CYTH3 DDX5 DNAJB6 EGFR FASLG FTL GABRB1 GLIS2 GNAQ GRIN2B HRAS IL13RA2 IL24 IL3 IRS2 IRS4 ITIH1 KRAS LCK MRAS MYC NEDD4L NEDD9 NRAS PDGFRA PDGFRB PDK1 PIK3R1 PIK3R3 PRKCD PSMC3IP PTPN11 RASD2 RASGRP3 RELA RPS20 RPS6KB1 SGK1 SH3KBP1 SMAD2 SMAD3 SNX9 SQSTM1 STAT1 STK11 THRSP TICAM1 TNFSF13 UFD1 UMPS VARS2
Entrez ID		11033	5290
HPRD ID		09733	01382
Ensembl ID		ENSG00000105963	ENSG00000121879
Uniprot IDs		A8K3A2 B4DUZ7 O75689	P42336 Q4LE51
PDB IDs		3FEH 3FM8 3LJU 3MDB	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1 5XGH 5XGI 5XGJ 6GVF 6GVG 6GVH 6GVI 6NCT 6OAC 6PYS
Enriched GO Terms of Interacting Partners?
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