TLK2 and MBP

Number of citations of the paper that reports this interaction (PubMedID 10523312)
52

Data Source:
HPRD (in vitro)

		TLK2	MBP
Description		tousled like kinase 2	myelin basic protein
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GO Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Permeability Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Interleukin-6 Secretion
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Lifespan ( 25918517)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		11 interacting genes: ASF1A ASF1B AURKA DCAF7 FEZ1 FEZ2 IRF4 IRF7 MBP TLK1 YWHAZ	72 interacting genes: ABL1 APTX ATN1 ATXN1 BMP2K CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTPRA RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		11011	4155
HPRD ID		10527	01158
Ensembl ID		ENSG00000146872	ENSG00000197971
Uniprot IDs		B4DUC2 J3QLK5 Q86UE8	A0A024R384 P02686
PDB IDs		5O0Y	1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?
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