MBP and STK3

Number of citations of the paper that reports this interaction (PubMedID 20212043)
21

Data Source:
BioGRID (enzymatic study)

		MBP	STK3
Description		myelin basic protein	serine/threonine kinase 3
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Permeability Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Interleukin-6 Secretion	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Regulation Of Mitotic Cell Cycle Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Signaling by Hippo
Drugs
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		72 interacting genes: ABL1 APTX ATN1 ATXN1 BMP2K CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTPRA RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	34 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 SAV1 SLMAP STK4 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		4155	6788
HPRD ID		01158	05433
Ensembl ID		ENSG00000197971	ENSG00000104375
Uniprot IDs		A0A024R384 P02686	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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