VAMP5 and MDC1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
46

Data Source:
BioGRID (two hybrid)

		VAMP5	MDC1
Description		vesicle associated membrane protein 5	mediator of DNA damage checkpoint 1
Image		No pdb structure
GO Annotations	Cellular Component	Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intercalated Disc Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	Protein Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Muscle Organ Development Skeletal Muscle Tissue Development Cell Differentiation Golgi To Plasma Membrane Protein Transport	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint
Pathways			SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Prostate cancer ( 21743467)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		4 interacting genes: LMNA MDC1 PLAC8 STX1A	39 interacting genes: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		10791	9656
HPRD ID		09513	16252
Ensembl ID		ENSG00000168899	ENSG00000137337
Uniprot IDs		O95183 Q6FG93	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs			2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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