NEK6 and PAK6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NEK6	PAK6
Description		NIMA related kinase 6	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Regulation Of Transcription, DNA-templated Apoptotic Process Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Activation of RAC1
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Vitiligo ( 27723757)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		43 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN PTPRD RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TASOR2 TCF4 TGFBR1 TLE5 TNK2 TRIM23 TRIM27 TRIP4 XIAP	18 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ SEMA3B SNX2 TPD52L1
Entrez ID		10783	56924
HPRD ID		05348	06426
Ensembl ID		ENSG00000119408	ENSG00000137843
Uniprot IDs		A0A024R8A6 Q9HC98	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8
Enriched GO Terms of Interacting Partners?
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