NEK6 and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NEK6	HSD17B14
Description		NIMA related kinase 6	hydroxysteroid 17-beta dehydrogenase 14
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Estrogen Biosynthetic Process Steroid Catabolic Process Oxidation-reduction Process
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Estrogen biosynthesis
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Vitiligo ( 27723757)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		43 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN PTPRD RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TASOR2 TCF4 TGFBR1 TLE5 TNK2 TRIM23 TRIM27 TRIP4 XIAP	16 interacting genes: CA8 CDKN2D CYTOR DDIT3 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 PHF1 PSMA1 SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		10783	51171
HPRD ID		05348	16801
Ensembl ID		ENSG00000119408	ENSG00000087076
Uniprot IDs		A0A024R8A6 Q9HC98	A0A140VJH8 Q9BPX1
PDB IDs			1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO
Enriched GO Terms of Interacting Partners?
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