PLK2 and CASK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PLK2	CASK
Description		polo like kinase 2	calcium/calmodulin dependent serine protein kinase
Image
GO Annotations	Cellular Component	Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Dendrite	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Vesicle Presynaptic Membrane Ciliary Membrane Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Protein Binding Protein-containing Complex Binding	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Dendritic Spine Development Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Neurotransmitter Secretion Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response	Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs			Formic Acid
Diseases			FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)
Interacting Genes		10 interacting genes: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA TSC1 TSC2	85 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DNAJC5 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WHRN WNT7B YWHAE
Entrez ID		10769	8573
HPRD ID		06118	02164
Ensembl ID		ENSG00000145632	ENSG00000147044
Uniprot IDs		A0A024QZV1 A0A087WUH9 Q9NYY3	A0A2R8Y6F8 A0A2R8YE77 O14936
PDB IDs		4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?
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