RAI1 and MAPK8IP2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		RAI1	MAPK8IP2
Description		retinoic acid induced 1	mitogen-activated protein kinase 8 interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Plasma Membrane Postsynaptic Density Protein-containing Complex Neuronal Cell Body
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Enhancer Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	Skeletal System Development Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Behavioral Fear Response Receptor-mediated Endocytosis Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Signaling Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Endocytosis Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Circadian Clock
Drugs
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Body mass index ( 28892062) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hip circumference ( 25673412) Lymphocyte counts ( 27863252) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458 30297969)	Hip circumference ( 28552196)
Interacting Genes		16 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TOPBP1 TTR ZNF496	84 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784 ZNRD1
Entrez ID		10743	23542
HPRD ID		07406	09674
Ensembl ID		ENSG00000108557	ENSG00000008735
Uniprot IDs		Q7Z5J4	Q13387
PDB IDs
Enriched GO Terms of Interacting Partners?
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