GNA13 and CXCR4

Number of citations of the paper that reports this interaction (PubMedID 11994484)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GNA13	CXCR4
Description		G protein subunit alpha 13	C-X-C motif chemokine receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome	Cell Nucleus Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Protein Binding Drug Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Identical Protein Binding Ubiquitin Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction	Activation Of MAPK Activity Response To Hypoxia Neuron Migration Epithelial Cell Development Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Brain Development Neuron Recognition Response To Virus Response To Activity Fusion Of Virus Membrane With Host Plasma Membrane Calcium-mediated Signaling Neurogenesis Telencephalon Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Vascular Wound Healing Cellular Response To Drug CXCL12-activated CXCR4 Signaling Pathway Regulation Of Programmed Cell Death Myelin Maintenance Response To Morphine Entry Into Host Endothelial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Viral Process Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cardiac Muscle Contraction Cell Chemotaxis Endothelial Tube Morphogenesis Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Dendrite Extension Positive Regulation Of Mesenchymal Stem Cell Migration Response To Ultrasound Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Framycetin AMD-070 Plerixafor
Diseases			Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		White matter microstructure (global fractional anisotropy) ( 24736177)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 19525953) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		10672	7852
HPRD ID		05100	01217
Ensembl ID		ENSG00000120063	ENSG00000121966
Uniprot IDs		A0A024R8M0 Q14344	A0A0U3FJG0 A0A0U3GXA9 P61073
PDB IDs			2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS
Enriched GO Terms of Interacting Partners?
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