RGS14 and GNAO1

Number of citations of the paper that reports this interaction (PubMedID 10926822)
31

Data Source:
HPRD (in vitro)

		RGS14	GNAO1
Description		regulator of G protein signaling 14	G protein subunit alpha o1
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Cell Junction Dendrite Dendritic Spine Glutamatergic Synapse	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Microtubule Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity GTPase Activating Protein Binding	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Mitotic Cell Cycle Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation G Protein-coupled Receptor Signaling Pathway Learning Long-term Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Visual Learning Positive Regulation Of Signal Transduction Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction
Pathways		G alpha (i) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood urea nitrogen levels ( 31152163) Calcium levels ( 24068962) Chronic kidney disease ( 31152163 20383146) Circulating fibroblast growth factor 23 levels ( 30217807) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602 21833088) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 27863252) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urolithiasis ( 30975718) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)
Interacting Genes		15 interacting genes: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A TINF2 TRAF2 WAS XPO1	34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		10636	2775
HPRD ID		03944	00757
Ensembl ID		ENSG00000169220	ENSG00000087258
Uniprot IDs		O43566	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs		2JNU 2OM2 2XNS 3ONW 3QI2	6FUF 6G79 6OIK
Enriched GO Terms of Interacting Partners?
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