TXNIP and TXN

Number of citations of the paper that reports this interaction (PubMedID 10419473)
173

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TXNIP	TXN
Description		thioredoxin interacting protein	thioredoxin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Cell Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	RNA Binding Thioredoxin-disulfide Reductase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Negative Regulation Of Transcription By RNA Polymerase II Glycerol Ether Metabolic Process Response To Radiation Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Oxidation-reduction Process Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection	Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Itch intensity from mosquito bite adjusted by bite size ( 28199695)
Interacting Genes		18 interacting genes: DDIT4 ECD FHL1 HDAC1 HDAC3 HSPB2 ITCH KPNA2 NLGN3 PRKAA1 PTPN11 SCEL SMURF2 TXN TXNRD1 UBR5 ZBTB16 ZBTB32	25 interacting genes: ACTN4 APEX1 CDKN1A COL1A1 COPS5 DNAJA1 DYNLT1 EGFR FST GFER GPRASP2 MAP3K5 MLH1 MYD88 NCF4 NFE2 NFKB1 NR3C1 PTEN SIAH1 SRPK2 TP53 TXNIP UCHL5 VIM
Entrez ID		10628	7295
HPRD ID		05964	01761
Ensembl ID		ENSG00000265972	ENSG00000136810
Uniprot IDs		Q9H3M7	H9ZYJ2 P10599
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD	1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY
Enriched GO Terms of Interacting Partners?
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