TRIM3 and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 10673389)
9

Data Source:
HPRD (two hybrid, in vivo)

		TRIM3	ACTN4
Description		tripartite motif containing 3	actinin alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Golgi Apparatus Dendrite	Stress Fiber Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Cytosol Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Nuclear Body Z Disc Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Protein Polyubiquitination Nervous System Development Protein Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Bicellular Tight Junction Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Protein Localization To Bicellular Tight Junction Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Interferon gamma signaling	Platelet degranulation Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS			Heart rate ( 23583979) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		12 interacting genes: ACTN4 CDKN1A KIF21B MYO5A TNFAIP3 UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2G2 UBE2K UBE2U	50 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		10612	81
HPRD ID		05690	05222
Ensembl ID		ENSG00000110171	ENSG00000130402
Uniprot IDs		B7Z5Y8 O75382	A0A0S2Z3G9 O43707
PDB IDs			1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?
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