CEBPD and SPI1

Number of citations of the paper that reports this interaction (PubMedID 7594592)
22

Data Source:
HPRD (in vitro)

		CEBPD	SPI1
Description		CCAAT enhancer binding protein delta	Spi-1 proto-oncogene
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Transcription Factor Binding NFAT Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development	Negative Regulation Of Transcription By RNA Polymerase II Lymphoid Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Population Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Pri-miRNA Transcription By RNA Polymerase II Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Transcriptional regulation of white adipocyte differentiation Interleukin-4 and Interleukin-13 signaling HCMV Late Events	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute myeloid leukemia (AML)
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum eosinophil basophil counts ( 27863252)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood urea nitrogen levels ( 31152163) C-reactive protein levels ( 30388399) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Global electrical heterogeneity phenotypes ( 29622589) Hematology traits ( 30576415) Intraocular pressure ( 29617998 25173106) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261)
Interacting Genes		18 interacting genes: CEBPA CEBPB CEBPE CEBPG CREBBP EP300 FBXW7 GSK3B HDAC3 HDAC4 PIAS4 RB1 RELA SMAD3 SMAD4 SPI1 TRIB1 UBE2I	45 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		1052	6688
HPRD ID		00297	01305
Ensembl ID		ENSG00000221869	ENSG00000066336
Uniprot IDs		P49716	P17947
PDB IDs
Enriched GO Terms of Interacting Partners?
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