CARM1 and SPAG8

Number of citations of the paper that reports this interaction (PubMedID 23455924)
38

Data Source:
BioGRID (two hybrid)

		CARM1	SPAG8
Description		coactivator associated arginine methyltransferase 1	sperm associated antigen 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Factor Complex	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Nuclear Receptor Transcription Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding	Molecular_function Protein Binding Microtubule Binding
	Biological Process	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Aging Positive Regulation Of Cell Proliferation Viral Process Histone Methylation Regulation Of Lipid Metabolic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Endochondral Bone Morphogenesis Protein Localization To Chromatin Regulation Of MRNA Binding Negative Regulation Of Dendrite Development	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression
Drugs
Diseases
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)	Blood protein levels ( 28240269)
Interacting Genes		32 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I	16 interacting genes: CARM1 CSTF2 DTX2 JMJD4 KDM3B KLHL32 NEDD4L NSD3 PITX1 PRMT1 PRMT2 PRMT5 RAN SIGMAR1 SNRPC UBQLN4
Entrez ID		10498	26206
HPRD ID		09158	12039
Ensembl ID		ENSG00000142453	ENSG00000137098
Uniprot IDs		Q86X55	A0A140VJV0 Q99932
PDB IDs		2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR
Enriched GO Terms of Interacting Partners?
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