MAD2L2 and CDH1

Number of citations of the paper that reports this interaction (PubMedID 11459826)
48

Data Source:
HPRD (in vitro)

		MAD2L2	CDH1
Description		mitotic arrest deficient 2 like 2	cadherin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Nucleolus Spindle Cytosol Zeta DNA Polymerase Complex Site Of Double-strand Break	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Double-strand Break Repair Actin Filament Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Synapse Assembly Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Negative Regulation Of Cell Migration Neuron Projection Development Adherens Junction Organization Entry Of Bacterium Into Host Cell Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription, DNA-templated Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI	Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells
Drugs
Diseases			Gastric cancer Penile cancer Nasopharyngeal cancer Breast cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)	Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Ulcerative colitis ( 19915572)
Interacting Genes		25 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 FZR1 IKZF1 KCTD9 MAD2L1 MAD2L1BP POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 SHLD1 SHLD2 TCF4 TRIM27 YY1AP1	53 interacting genes: ACTR3 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBIN EZR FER FGFR1 FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MDM2 MYO6 NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 STOML2 UCHL3 VCL YES1
Entrez ID		10459	999
HPRD ID		07246	01885
Ensembl ID		ENSG00000116670	ENSG00000039068
Uniprot IDs		A0A024R4I4 Q9UI95	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6KEA 6NIF	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG
Enriched GO Terms of Interacting Partners?
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