MAD2L2 and SHLD2

Number of citations of the paper that reports this interaction (PubMedID 30254264)
5

Data Source:
BioGRID (pull down)

		MAD2L2	SHLD2
Description		mitotic arrest deficient 2 like 2	shieldin complex subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Nucleolus Spindle Cytosol Zeta DNA Polymerase Complex Site Of Double-strand Break	Nucleus Chromosome Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Double-strand Break Repair Actin Filament Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	DNA Repair Positive Regulation Of Isotype Switching Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		25 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 FZR1 IKZF1 KCTD9 MAD2L1 MAD2L1BP POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 SHLD1 SHLD2 TCF4 TRIM27 YY1AP1	2 interacting genes: MAD2L2 SHLD1
Entrez ID		10459	54537
HPRD ID		07246	09944
Ensembl ID		ENSG00000116670	ENSG00000122376
Uniprot IDs		A0A024R4I4 Q9UI95	Q86V20
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6KEA 6NIF
Enriched GO Terms of Interacting Partners?
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