ACAA2 and SCP2

Number of citations of the paper that reports this interaction (PubMedID 10856712)
27

Data Source:
HPRD (in vitro)

		ACAA2	SCP2
Description		acetyl-CoA acyltransferase 2	sterol carrier protein 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA Hydrolase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Palmitoyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity	Fatty-acyl-CoA Binding Signaling Receptor Binding Protein Binding Cholesterol Binding Sterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Oleic Acid Binding
	Biological Process	Fatty Acid Beta-oxidation Cholesterol Biosynthetic Process Cellular Response To Hypoxia Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Protein Targeting To Peroxisome Steroid Biosynthetic Process Bile Acid Biosynthetic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Lipid Hydroperoxide Transport
Pathways		Mitochondrial Fatty Acid Beta-Oxidation	alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs
Diseases			Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia Leukoencephalopathy with dystonia and motor neuropathy
GWAS		Apolipoprotein A1 levels ( 29084231) Cholesterol ester levels in very large HDL ( 29084231) Free cholesterol levels in medium HDL ( 29084231) HDL cholesterol ( 18193044) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heschl's gyrus morphology ( 25130324) Large HDL particle concentration ( 29084231) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		4 interacting genes: APP HSPB2 SCP2 TERT	9 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CREB3 EHHADH PEX5 PITPNA TRIP13
Entrez ID		10449	6342
HPRD ID		10380	01700
Ensembl ID		ENSG00000167315	ENSG00000116171
Uniprot IDs		B3KNP8 P42765	A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9
PDB IDs		4C2J 4C2K	1QND 2C0L
Enriched GO Terms of Interacting Partners?
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