ACAA2 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
5

Data Source:
BioGRID (two hybrid)

		ACAA2	HSPB2
Description		acetyl-CoA acyltransferase 2	heat shock protein family B (small) member 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA Hydrolase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Palmitoyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity	Protein Binding Enzyme Activator Activity
	Biological Process	Fatty Acid Beta-oxidation Cholesterol Biosynthetic Process Cellular Response To Hypoxia Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Response To Unfolded Protein Positive Regulation Of Catalytic Activity
Pathways		Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 29084231) Cholesterol ester levels in very large HDL ( 29084231) Free cholesterol levels in medium HDL ( 29084231) HDL cholesterol ( 18193044) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heschl's gyrus morphology ( 25130324) Large HDL particle concentration ( 29084231) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		4 interacting genes: APP HSPB2 SCP2 TERT	89 interacting genes: A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BEX4 BGN C1QA CAPZA2 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DDX10 DMPK DUSP1 EEF1A1 EIF4A2 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HSPB3 HSPB8 LGALS1 MAPKAPK5 MB MCCC2 MDH1 MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PGM1 PKP2 PPM1K RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 TATDN1 TCAP THEMIS2 THUMPD2 TNNI3 TTN TXNIP UBL5 WDR1 ZNF335
Entrez ID		10449	3316
HPRD ID		10380	03712
Ensembl ID		ENSG00000167315	ENSG00000170276
Uniprot IDs		B3KNP8 P42765	A8KAH6 Q16082
PDB IDs		4C2J 4C2K	6F2R
Enriched GO Terms of Interacting Partners?
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