C1D and NR1D1

Number of citations of the paper that reports this interaction (PubMedID 9405624)
37

Data Source:
BioGRID (pull down, affinity chromatography technology)

		C1D	NR1D1
Description		C1D nuclear receptor corepressor	nuclear receptor subfamily 1 group D member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Transcriptional Repressor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Cell Junction Dendrite Dendritic Spine RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Transcription Corepressor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Heme Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Regulatory Region DNA Binding E-box Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Circadian Rhythm Hormone-mediated Signaling Pathway Proteasomal Protein Catabolic Process Negative Regulation Of Receptor Biosynthetic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Protein Destabilization Circadian Regulation Of Gene Expression Response To Lipid Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Sleep/wake Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Activation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Microglial Cell Activation
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Circadian Clock Circadian Clock
Drugs
Diseases
GWAS		Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) Restless legs syndrome ( 29029846) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Asthma ( 31619474) Multiple sclerosis ( 31604244) White blood cell count ( 21738480)
Interacting Genes		12 interacting genes: APP IL23R MOGS NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 THRA THRB TSNAX	7 interacting genes: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3
Entrez ID		10438	9572
HPRD ID		07382	03873
Ensembl ID		ENSG00000197223	ENSG00000126368
Uniprot IDs		Q13901	F1D8S3 P20393
PDB IDs			1A6Y 1EF6 1GA5 1HLZ 3N00
Enriched GO Terms of Interacting Partners?
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