DLC1 and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 16338927)
11

Data Source:
BioGRID (enzymatic study)

		DLC1	RPS6KA1
Description		DLC1 Rho GTPase activating protein	ribosomal protein S6 kinase A1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Caveola Focal Adhesion Cortical Actin Cytoskeleton Ruffle Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Neural Tube Closure Heart Morphogenesis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Dephosphorylation Positive Regulation Of GTPase Activity Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis	Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Rho GTPase cycle	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Purvalanol A
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Glucose homeostasis traits ( 25524916) Mean corpuscular volume ( 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155)
Interacting Genes		4 interacting genes: AKT1 PTEN RPS6KA1 TNS2	86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		10395	6195
HPRD ID		05035	03402
Ensembl ID		ENSG00000164741	ENSG00000117676
Uniprot IDs		A8K119 Q96QB1	Q15418
PDB IDs		2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62
Enriched GO Terms of Interacting Partners?
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