RRAGB and DEPDC5

Number of citations of the paper that reports this interaction (PubMedID 23723238)
302

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RRAGB	DEPDC5
Description		Ras related GTP binding B	DEP domain containing 5, GATOR1 subcomplex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Cytosol EGO Complex Gtr1-Gtr2 GTPase Complex	Lysosome Lysosomal Membrane Cytosol Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Guanyl Ribonucleotide Binding GTPase Binding	GTPase Activator Activity Protein-containing Complex Binding
	Biological Process	Cell Cycle Arrest Cellular Response To Starvation Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Cellular Response To Amino Acid Stimulus Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of TORC1 Signaling
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Male-pattern baldness ( 27182965) Prostate-specific antigen levels ( 28139693) Smoking initiation ( 24665060)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Type 2 diabetes ( 30130595)
Interacting Genes		6 interacting genes: APP DEPDC5 MTOR RPTOR RRAGC RRAGD	2 interacting genes: RRAGB RRAGC
Entrez ID		10325	9681
HPRD ID		06710	16795
Ensembl ID		ENSG00000083750	ENSG00000100150
Uniprot IDs		Q5VZM2	O75140
PDB IDs			6CES 6CET
Enriched GO Terms of Interacting Partners?
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