DEPDC5 and RRAGC

Number of citations of the paper that reports this interaction (PubMedID 23723238)
302

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		DEPDC5	RRAGC
Description		DEP domain containing 5, GATOR1 subcomplex subunit	Ras related GTP binding C
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol EGO Complex Intracellular Membrane-bounded Organelle Gtr1-Gtr2 GTPase Complex
	Molecular Function	GTPase Activator Activity Protein-containing Complex Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Heterodimerization Activity GTPase Binding
	Biological Process	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of TORC1 Signaling	Transcription, DNA-templated Apoptotic Process Cell Cycle Arrest Small GTPase Mediated Signal Transduction RNA Splicing Cellular Response To Starvation Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Response To Amino Acid Cellular Response To Amino Acid Stimulus Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1	Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Type 2 diabetes ( 30130595)	Beard thickness ( 26926045) Blood protein levels ( 28240269)
Interacting Genes		2 interacting genes: RRAGB RRAGC	7 interacting genes: ATXN1L DEPDC5 MPP3 NOL8 RRAGA RRAGB WNT2
Entrez ID		9681	64121
HPRD ID		16795	12198
Ensembl ID		ENSG00000100150	ENSG00000116954
Uniprot IDs		O75140	B4DQ03 B4DQG4 Q9HB90
PDB IDs		6CES 6CET	3LLU 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG
Enriched GO Terms of Interacting Partners?
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