CDKN2D and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CDKN2D	HSD17B14
Description		cyclin dependent kinase inhibitor 2D	hydroxysteroid 17-beta dehydrogenase 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cyclin D2-CDK4 Complex	Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair Cell Cycle Arrest Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Response To UV Negative Regulation Of Cell Growth Response To Retinoic Acid Response To Vitamin D Negative Regulation Of Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Autophagic Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Estrogen Biosynthetic Process Steroid Catabolic Process Oxidation-reduction Process
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Estrogen biosynthesis
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		22 interacting genes: APP BRCA1 BTG1 C1orf94 CDK4 CDK6 CTBP1 DMRTB1 FHL3 HSD17B14 IKZF3 INCA1 LSM3 NMI NR4A1 NR4A2 QKI SH3GLB1 SH3GLB2 TBC1D17 TEX11 TSG101	16 interacting genes: CA8 CDKN2D CYTOR DDIT3 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 PHF1 PSMA1 SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		1032	51171
HPRD ID		02957	16801
Ensembl ID		ENSG00000129355	ENSG00000087076
Uniprot IDs		A0A024R796 P55273	A0A140VJH8 Q9BPX1
PDB IDs		1BD8 1BI8	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO
Enriched GO Terms of Interacting Partners?
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