TNIP1 and VPS33B

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		TNIP1	VPS33B
Description		TNFAIP3 interacting protein 1	VPS33B late endosome and lysosome associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cytoplasm Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Clathrin-coated Vesicle HOPS Complex Platelet Alpha Granule Early Endosome Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Protein Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Protein Deubiquitination	Vesicle Docking Involved In Exocytosis Endosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Peptidyl-lysine Hydroxylation Melanosome Localization Lysosome Localization Collagen Metabolic Process Membrane Fusion Platelet Alpha Granule Organization Autophagosome Maturation
Pathways		Ovarian tumor domain proteases	Prevention of phagosomal-lysosomal fusion
Drugs
Diseases			Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome
GWAS		Amyotrophic lateral sclerosis ( 29566793) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Inflammatory skin disease ( 25574825) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25854761 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis (ACPA-positive) ( 23143596) SjÃ¶gren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26606652 23273568 26502338 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 31672989 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Feeling hurt ( 29500382)
Interacting Genes		66 interacting genes: ABHD17A ADH6 AP1M1 BYSL CCDC112 CCDC121 CCNG1 CDIP1 CDKN1A CFAP53 EFEMP1 EHHADH FAM161A FAM168A FUS GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 HDAC1 HDDC3 IKBKG KIFC3 MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP3K1 MAPK1 MAPK10 MCM10 MOB1B MOB3C MORF4L1 MORF4L2 NDC80 NFKB1 NIFK NME7 NOD2 PIN1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RPL5 S100B SELPLG SNIP1 SUMO2 SYT6 TCEA2 TCEANC2 TNFAIP3 TNIP3 TTF2 TXLNA TYRO3 UBC VPS33B ZBTB25 ZNHIT1	6 interacting genes: APP MAP3K20 MAPK8IP2 TNIP1 UVRAG VIPAS39
Entrez ID		10318	26276
HPRD ID		09216	10541
Ensembl ID		ENSG00000145901	ENSG00000184056
Uniprot IDs		A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025	A0A0S2Z577 B7Z1N4 F5H008 Q9H267
PDB IDs
Enriched GO Terms of Interacting Partners?
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