CDKN2C and TCF4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CDKN2C	TCF4
Description		cyclin dependent kinase inhibitor 2C	transcription factor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nuclear Chromatin Nucleus Transcription Factor Complex Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Oligodendrocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Assembly
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Myogenesis Myogenesis
Drugs
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Atrial fibrillation ( 29290336) Height ( 31562340) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)	Ability to confide in someone ( 29970889) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Automobile speeding propensity ( 30643258) Bitter alcoholic beverage consumption ( 31046077) Broad depression or schizophrenia ( 30626913) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal endothelial cell density ( 30894546) Corneal endothelial cell shape (percentage of hexagonally shaped cells) ( 30894546) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Depression ( 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Feeling worry ( 29500382) Fuchs's corneal dystrophy ( 28358029 20825314) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431 29313844) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intraocular pressure ( 29617998 31798171 29235454) Irritable mood ( 29500382) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Male-pattern baldness ( 28196072) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Morning person ( 30696823) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity (early onset extreme) ( 23563609) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Pulse pressure ( 30578418) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 21926974 19571808 19571811 29483656 22688191 30285260 23974872 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Self-rated health ( 27864402) Self-reported risk-taking behaviour ( 30271922) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Type 2 diabetes ( 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		51 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PDGFRA PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 ST14 STK11 TCF12 TCF4 TLE1 TP53 UNC119	174 interacting genes: AQP1 AR ARHGEF1 ARMC7 ASCL1 ASCL3 ASCL4 ASPSCR1 ATP6V1B2 BACH1 BCAS2 BCL2L2 C1orf109 CABP5 CALM1 CALM2 CALM3 CDC73 CDKN1A CDKN2C CFAP77 CHAF1A CHCHD2 CHIC2 CKS1B CTBP1 CTNNB1 DAXX DDX6 DEF6 DGCR6 DMRT3 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOSC1 FAH FAM124B FAM74A4 FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 LASP1 LENG1 LGALS14 LHX4 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MATN3 MEMO1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSRB3 MVP MYO5B MYOD1 NCK2 NDOR1 NEK6 NEK8 NEU4 NEUROD1 NEUROG1 NME7 NMUR2 NOL9 NR2C2AP NR4A1 NUDT10 ORC4 OSGIN1 OTUD4 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PRKACA PRKN PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RECK RELA REXO1L6P RNF6 RSPH14 RUNX1T1 SCOC SEC14L4 SHFL SIGLEC6 SLC39A13 SLC4A1AP SMCP SMOC1 SPATC1L SPG21 SRSF2 STAMBPL1 STK16 STX11 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF3 TCL1A TLE1 TLE5 TMEM213 TP53 TRAPPC2L TSPOAP1 TSSC4 TSSK3 TWIST1 TWIST2 TXNL4B UBE2I UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZNF124 ZNF205-AS1 ZNF417 ZNF587 ZNF688
Entrez ID		1031	6925
HPRD ID		04534	03780
Ensembl ID		ENSG00000123080	ENSG00000196628
Uniprot IDs		P42773 Q6ICV4	A0A024R2C0 A0A1B0GW91 A0A1B0GWD5 A0A590UK26 B3KVA4 E9PH57 H3BPJ7 H3BTP3 P15884
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6	2KWF 6OD3 6OD4 6OD5
Enriched GO Terms of Interacting Partners?
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