TCF4 and CALM3

Number of citations of the paper that reports this interaction (PubMedID 10757985)
10

Data Source:
HPRD (in vitro)

		TCF4	CALM3
Description		transcription factor 4	calmodulin 3
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex	Spindle Pole Cell Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Sarcomere Growth Cone Synaptic Vesicle Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Calcium Channel Complex Myelin Sheath Catalytic Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity E-box Binding	Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Protein Kinase Binding Protein Domain Specific Binding Enzyme Regulator Activity Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding N-terminal Myristoylation Domain Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Ion Channel Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity Disordered Domain Specific Binding
	Biological Process	DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Assembly	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Response To Amphetamine Regulation Of Heart Rate Detection Of Calcium Ion G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium-mediated Signaling Substantia Nigra Development Positive Regulation Of Protein Autophosphorylation Regulation Of Cytokinesis Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Positive Regulation Of DNA Binding Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Establishment Of Protein Localization To Mitochondrial Membrane Regulation Of Synaptic Vesicle Endocytosis Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Synaptic Vesicle Exocytosis
Pathways		Myogenesis Myogenesis	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation Signaling downstream of RAS mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine 3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine 2-Methyl-2-Propanol N-Trimethyllysine N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium Citrate Calcium Citrate Calcium Citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Ability to confide in someone ( 29970889) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Automobile speeding propensity ( 30643258) Bitter alcoholic beverage consumption ( 31046077) Broad depression or schizophrenia ( 30626913) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal endothelial cell density ( 30894546) Corneal endothelial cell shape (percentage of hexagonally shaped cells) ( 30894546) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Depression ( 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Feeling worry ( 29500382) Fuchs's corneal dystrophy ( 28358029 20825314) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431 29313844) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intraocular pressure ( 29617998 31798171 29235454) Irritable mood ( 29500382) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Male-pattern baldness ( 28196072) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Morning person ( 30696823) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity (early onset extreme) ( 23563609) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Pulse pressure ( 30578418) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 21926974 19571808 19571811 29483656 22688191 30285260 23974872 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Self-rated health ( 27864402) Self-reported risk-taking behaviour ( 30271922) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Type 2 diabetes ( 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Crohn's disease ( 28067908) Ulcerative colitis ( 23128233)
Interacting Genes		174 interacting genes: AQP1 AR ARHGEF1 ARMC7 ASCL1 ASCL3 ASCL4 ASPSCR1 ATP6V1B2 BACH1 BCAS2 BCL2L2 C1orf109 CABP5 CALM1 CALM2 CALM3 CDC73 CDKN1A CDKN2C CFAP77 CHAF1A CHCHD2 CHIC2 CKS1B CTBP1 CTNNB1 DAXX DDX6 DEF6 DGCR6 DMRT3 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOSC1 FAH FAM124B FAM74A4 FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 LASP1 LENG1 LGALS14 LHX4 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MATN3 MEMO1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSRB3 MVP MYO5B MYOD1 NCK2 NDOR1 NEK6 NEK8 NEU4 NEUROD1 NEUROG1 NME7 NMUR2 NOL9 NR2C2AP NR4A1 NUDT10 ORC4 OSGIN1 OTUD4 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PRKACA PRKN PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RECK RELA REXO1L6P RNF6 RSPH14 RUNX1T1 SCOC SEC14L4 SHFL SIGLEC6 SLC39A13 SLC4A1AP SMCP SMOC1 SPATC1L SPG21 SRSF2 STAMBPL1 STK16 STX11 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF3 TCL1A TLE1 TLE5 TMEM213 TP53 TRAPPC2L TSPOAP1 TSSC4 TSSK3 TWIST1 TWIST2 TXNL4B UBE2I UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZNF124 ZNF205-AS1 ZNF417 ZNF587 ZNF688	35 interacting genes: AKAP9 APPBP2 ASCL2 C11orf65 CACNA1A CALD1 CAMTA2 CCND2 CCP110 CLEC7A EDF1 EGFR ESR1 ESR2 GRM5 GRM7 INSR IQCE IQCN KCNQ2 KCNQ3 KCNQ5 MINK1 MYF5 MYF6 MYOD1 MYOG NEUROD1 PLCB3 PPEF1 PPEF2 RAB3B TCF3 TCF4 TRIM54
Entrez ID		6925	808
HPRD ID		03780	00243
Ensembl ID		ENSG00000196628	ENSG00000160014
Uniprot IDs		A0A024R2C0 A0A1B0GW91 A0A1B0GWD5 A0A590UK26 B3KVA4 E9PH57 H3BPJ7 H3BTP3 P15884	B4DJ51 P0DP23 P0DP24 P0DP25 Q96HY3 Q9BRL5
PDB IDs		2KWF 6OD3 6OD4 6OD5	1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DBR 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5JQA 5JTH 5K7L 5K8Q 5NIN 5OEO 5TP5 5TP6 5V02 5V03 5V7X 5VMS 5WBX 5WC5 5WSU 5WSV 6B8L 6B8M 6B8N 6B8P 6B8Q 6BUT 6C1D 6C1G 6C1H 6CNM 6CNN 6CNO 6DAD 6DAE 6DAF 6DAH 6E2F 6E2G 6EEB 6FEG 6FEH 6GDK 6GDL 6HCS 6JI8 6JII 6JIU 6JIY 6JRS 6JV2 6K4K 6K4L 6K4R 6MUD 6MUE 6N5W 6O5G 6PBX 6PBY 6PLM 6S5T
Enriched GO Terms of Interacting Partners?
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