BCKDK and SETD1A

		BCKDK	SETD1A
Description		branched chain keto acid dehydrogenase kinase	SET domain containing 1A, histone lysine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity	RNA Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Phosphorylation Glucose Homeostasis Negative Regulation Of Pyruvate Dehydrogenase Activity	Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization
Pathways		Branched-chain amino acid catabolism	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Adenosine 5'-[Î³-thio]triphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 27863252) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		17 interacting genes: APP BCKDHB CDIPT EIF3C EPS8 FBXO7 FOXO1 GUCA1A LSM8 NR5A2 PCDHB9 QPRT SETD1A STAT3 TAOK2 TRAF4 ZNF267	6 interacting genes: BCKDK DPY30 EP300 H3C1 H3C14 LBP
Entrez ID		10295	9739
HPRD ID		12523	13795
Ensembl ID		ENSG00000103507	ENSG00000099381
Uniprot IDs		A0A024QZA9 O14874	O15047
PDB IDs			3S8S 3UVN 4EWR
Enriched GO Terms of Interacting Partners?
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