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CDKN2A and FN1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
75
Data Source:
BioGRID
(two hybrid)
CDKN2A
FN1
Description
cyclin dependent kinase inhibitor 2A
fibronectin 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Senescence-associated Heterochromatin Focus
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
RNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
NF-kappaB Binding
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Protein C-terminus Binding
Heparin Binding
Peptidase Activator Activity
Enzyme Binding
Identical Protein Binding
Proteoglycan Binding
Chaperone Binding
Disordered Domain Specific Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell-matrix Adhesion
Cell Cycle Arrest
Ras Protein Signal Transduction
Negative Regulation Of Cell Proliferation
Negative Regulation Of Cell Growth
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Senescence-associated Heterochromatin Focus Assembly
Negative Regulation Of Phosphorylation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Cellular Senescence
Replicative Senescence
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cellular Senescence
Angiogenesis
Regulation Of Protein Phosphorylation
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidase Activity
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Leukocyte Migration
Interaction With Symbiont
Regulation Of ERK1 And ERK2 Cascade
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Negative Regulation Of Transforming Growth Factor-beta Secretion
Pathways
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Transcriptional Regulation by VENTX
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Apoptotic factor-mediated response
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
Regulation of TP53 Degradation
Stabilization of p53
Regulation of RUNX3 expression and activity
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Evasion of Oncogene Induced Senescence Due to p14ARF Defects
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Drugs
Zinc
Ocriplasmin
Diseases
Bladder cancer
Type II diabetes mellitus
Pancreatic cancer
Burkitt lymphoma
Adult T-cell leukemia
Malignant pleural mesothelioma
Non-small cell lung cancer
Chronic myeloid leukemia (CML)
Oral cancer
Penile cancer
Nasopharyngeal cancer
Glioma
Osteosarcoma
Squamous cell carcinoma
Cholangiocarcinoma
Gallbladder cancer
Malignant islet cell carcinoma
Laryngeal cancer
Hepatocellular carcinoma
Esophageal cancer
Malignant melanoma
GWAS
Abdominal aortic aneurysm (
20622881
)
Acute lymphoblastic leukemia (childhood) (
29348612
)
Acute lymphoblastic leukemia in childhood (B cell precursor) (
29632299
)
B-cell acute lymphoblastic leukaemia (
31767839
)
Basal cell carcinoma (
24403052
25855136
)
Breast cancer (
29059683
23535729
20453838
)
Coronary artery calcification (
23561647
)
Coronary artery disease (
21239051
29263402
26708285
)
Coronary heart disease (
21971053
17554300
21378990
)
Coronary heart disease (SNP X SNP interaction) (
21626137
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometriosis (
23104006
)
Esophageal squamous cell carcinoma (
25129146
)
Fasting plasma glucose (
25187374
)
Glioblastoma (
28346443
)
Glioma (
28346443
21531791
19578367
)
Inflammatory bowel disease (
27569725
)
Intracranial aneurysm (
18997786
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Lymphocyte counts (
27863252
)
Melanoma (
21983787
28212542
19578364
)
Monocyte count (
27863252
)
Multiple myeloma (
27363682
)
Myocardial infarction (
17478679
26708285
)
Myocardial infarction (early onset) (
19198609
)
Nasopharyngeal carcinoma (
26545403
)
Non-glioblastoma glioma (
28346443
)
Non-small cell lung cancer (
31326317
)
Parental longevity (both parents in top 10%) (
29227965
)
Parental longevity (father's age at death) (
29227965
)
Platelet count (
22139419
27863252
)
Plateletcrit (
27863252
)
Type 2 diabetes (
21573907
27189021
18372903
24509480
26961502
29358691
30297969
26818947
23945395
20581827
19401414
17463246
30718926
17463248
17463249
23209189
)
White blood cell count (
27863252
)
Blood protein levels (
30072576
28240269
)
Cholesterol, total (
26780889
)
Coronary artery disease (
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
)
Negative urgency (
30718321
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
30578418
)
Total cholesterol levels (
28334899
)
Interacting Genes
150 interacting genes:
-
ACLY
ACTB
ACTG1
ACTN4
AHNAK
AKT1
ANAPC15
ANGPTL4
ANKRA2
ANKRD12
ARFIP2
ARNT
ASPRV1
AZIN1
BCL2L1
BECN1
CARF
CASC3
CCDC183
CCND2
CCNDBP1
CCNE1
CCNG1
CD44
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2B
CDKN2C
CENPA
CRELD2
CTBP2
DEAF1
E2F1
E4F1
EEF2
EFHC2
EGR1
EPHA2
EPHA3
EXOC2
FGFR4
FN1
FZR1
GAPDH
GGA1
GGA3
GLIS1
GLIS2
GMNN
GSPT1
H2BU1
HGF
HIF1A
HLA-DOB
HNRNPA2B1
HNRNPC
HNRNPU
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
ISOC2
KAT5
LAMTOR3
LATS2
MAF1
MAP2K5
MAP3K5
MAPK10
MAPK14
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MDM4
MMRN1
MTR
MYC
MYL12A
NAT2
NCL
NMI
NOP53
NPM1
NSD3
ORC4
PCNA
PDCD6
PDGFRA
PEX19
PPP1R9B
PRKCA
PSMC3
PTP4A3
RAF1
RASSF1
RBM26
RIN2
RPL11
RPS7
RUVBL2
SERTAD1
SIVA1
SIX2
SLC4A1
SMARCA4
SNRPA
SNRPB
SOX3
SOX4
STK11
TBRG1
TDRD7
TEAD2
TERT
TFDP1
TP53
TP63
TPI1
TRIM28
TRIP12
TSC1
TUBA1A
TUBA1C
TUBB
TUBB4B
UBE2A
UBE4B
UBL7
USP26
VAMP1
VHL
WRN
YY1
ZFP91
ZGRF1
ZNF227
ZNF410
ZNF420
ZNF687
ZUP1
103 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NPTX1
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TMPRSS6
TNC
TNFRSF11B
TSHR
UBQLN1
VEGFA
VHL
Entrez ID
1029
2335
HPRD ID
02542
00626
Ensembl ID
ENSG00000147889
ENSG00000115414
Uniprot IDs
K7PML8
P42771
Q8N726
B7ZLE5
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
PDB IDs
1A5E
1BI7
1DC2
2A5E
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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