CWC27 and GTF2H2

		CWC27	GTF2H2
Description		CWC27 spliceosome associated cyclophilin	general transcription factor IIH subunit 2
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GO Annotations	Cellular Component	Nucleoplasm U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Cyclosporin A Binding	Nucleic Acid Binding Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity Zinc Ion Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity RNA Polymerase II General Transcription Initiation Factor Activity Protein N-terminus Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Nucleotide-excision Repair, DNA Duplex Unwinding G Protein-coupled Receptor Internalization Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Response To UV Viral Process Nucleotide-excision Repair, DNA Incision Global Genome Nucleotide-excision Repair Positive Regulation Of DNA Helicase Activity
Pathways		mRNA Splicing - Major Pathway	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Bladder cancer ( 27206850) Central corneal thickness ( 31798171 29760442) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Obesity-related traits ( 23251661) Systolic blood pressure ( 30224653) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		10 interacting genes: CLK1 ERBIN FRA10AC1 GTF2H2 HMGA1 NLN PPWD1 RNF180 SGTB TRAPPC13	14 interacting genes: AR CDK7 CWC27 DNMT3L ERCC2 ERCC3 ERCC8 ERRFI1 GTF2H1 GTF2H3 GTF2H4 GTF2H5 MNAT1 SRA1
Entrez ID		10283	2966
HPRD ID		11541	03450
Ensembl ID		ENSG00000153015	ENSG00000145736
Uniprot IDs		D6REK3 Q6UX04	Q13888
PDB IDs		2HQ6 4R3E 5Z56 5Z58 6FF4 6FF7	1Z60 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 6NMI 6O9L 6O9M 6RO4
Enriched GO Terms of Interacting Partners?
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