CDKN1A and GAPDH

Number of citations of the paper that reports this interaction (PubMedID 16474839)
16

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CDKN1A	GAPDH
Description		cyclin dependent kinase inhibitor 1A	glyceraldehyde-3-phosphate dehydrogenase
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body Protein-containing Complex Perinuclear Region Of Cytoplasm PCNA-p21 Complex	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Cyclin-dependent Protein Kinase Activating Kinase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Aspartic-type Endopeptidase Inhibitor Activity Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding Disordered Domain Specific Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Heart Development Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To X-ray Response To Organonitrogen Compound Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Cellular Response To Amino Acid Starvation Cellular Response To Heat Tissue Regeneration Negative Regulation Of Phosphorylation Response To Drug Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Response To Arsenic-containing Substance Positive Regulation Of Fibroblast Proliferation Protein Stabilization Response To Corticosterone Response To Hyperoxia Intestinal Epithelial Cell Maturation Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Mitotic Cell Cycle Arrest Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Microtubule Cytoskeleton Organization Gluconeogenesis Glycolytic Process Negative Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Negative Regulation Of Translation Killing Of Cells Of Other Organism Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Cytokine Secretion Protein Stabilization Defense Response To Fungus Neuron Apoptotic Process Killing By Host Of Symbiont Cells Positive Regulation By Organism Of Apoptotic Process In Other Organism Involved In Symbiotic Interaction Canonical Glycolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Interferon-gamma
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes	Glycolysis Gluconeogenesis
Drugs		Arsenic trioxide	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper
Diseases		Cervical cancer
GWAS		Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 22634755 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Ischemic stroke ( 29531354) Left ventricular fractional shortening ( 28394258) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420 31217584 21076409 27659466) Triglycerides ( 27036123)	Blood protein levels ( 30072576)
Interacting Genes		188 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOXD8 HPD IKBKG IKZF3 ING5 INPP5K KLHL23 KMT2B KRT31 LATS2 LRIF1 LRR1 MAP3K5 MAPK8 MCM10 MED31 MSH2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PRKACA PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RB1 RBBP4 RBM48 RNF126 RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SDF4 SET SETDB1 SIPA1 SKP1 SKP2 SLC25A11 SP110 SPRED1 STAT3 STUB1 SUMO3 TAF5L TCF4 TEX11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TP53 TRAF1 TRIM3 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USP11 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431	79 interacting genes: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FBXO7 FKBP6 GADD45A GAS7 GOT2 GRIA2 GRM1 HES1 HNF4G HSPB2 HTT KARS1 KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MTNR1A MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 PTPRF RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ
Entrez ID		1026	2597
HPRD ID		00298	00713
Ensembl ID		ENSG00000124762	ENSG00000111640
Uniprot IDs		A0A024RCX5 P38936	P04406 V9HVZ4
PDB IDs		1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX	1U8F 1ZNQ 2FEH 3GPD 4WNC 4WNI 6ADE 6IQ6
Enriched GO Terms of Interacting Partners?
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