GPHN and PFN1

Number of citations of the paper that reports this interaction (PubMedID 9473484)
33

Data Source:
HPRD (in vitro)

		GPHN	PFN1
Description		gephyrin	profilin 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Cell Junction Dendrite Postsynaptic Membrane Postsynaptic Specialization Postsynaptic Specialization Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Protein Binding ATP Binding Nitrate Reductase Activity Molybdopterin Cofactor Binding Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Adenyl-nucleotide Exchange Factor Activity RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Cadherin Binding Proline-rich Region Binding
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Oxidation-reduction Process Glycine Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Postsynaptic Neurotransmitter Receptor Diffusion Trapping	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly
Pathways		Molybdenum cofactor biosynthesis	Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Formic Acid Imidazole Propanoic Acid	7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases		Hyperekplexia
GWAS		Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		13 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MTOR PFN1 PIN1 SPATS1 TUBA4A	33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ
Entrez ID		10243	5216
HPRD ID		04893	01452
Ensembl ID		ENSG00000171723	ENSG00000108518
Uniprot IDs		Q9NQX3	P07737
PDB IDs		1JLJ	1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25
Enriched GO Terms of Interacting Partners?
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