RBM5 and PKP2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		RBM5	PKP2
Description		RNA binding motif protein 5	plakophilin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Metal Ion Binding	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		mRNA Splicing - Major Pathway	Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Age at first birth ( 27798627) Blood protein levels ( 28240269) Body mass index ( 26426971) Dentures ( 31235808) Extremely high intelligence ( 29520040) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Morning person ( 30696823) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Regular attendance at a gym or sports club ( 29970889) Sleep duration (short sleep) ( 30846698)	Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		22 interacting genes: BCL2L1 CASK DCX DDX17 GAPDH ILF3 KIF19 KIF9 LIG4 LRIF1 LSM8 MED1 MEOX1 MEOX2 NDEL1 PARD3B PCM1 PKP2 RBM14 WBP11 WDR77 ZDHHC17	26 interacting genes: AKAP9 CASK CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP GTF2IRD1 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A RBM5 SINHCAF SMAD9 YWHAG
Entrez ID		10181	5318
HPRD ID		06052	04177
Ensembl ID		ENSG00000003756	ENSG00000057294
Uniprot IDs		A0A024R2U6 P52756	Q99959
PDB IDs		2LK0 2LK1 2LKZ 5MF9 5MFY	3TT9
Enriched GO Terms of Interacting Partners?
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