CDK3 and CCNE2

Number of citations of the paper that reports this interaction (PubMedID 9840943)
35

Data Source:
HPRD (two hybrid)

		CDK3	CCNE2
Description		cyclin dependent kinase 3	cyclin E2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Synapsis Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cellular Protein Localization
Pathways			G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition p53-Dependent G1 DNA Damage Response
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS
Interacting Genes		18 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCNE1 CCNE2 CDC37 CDKN1A CDKN1B CDKN3 E2F1 E2F2 E2F3 KIR3DL1 NEDD4L PPARA RB1	12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		1018	9134
HPRD ID		00446	04801
Ensembl ID		ENSG00000250506	ENSG00000175305
Uniprot IDs		Q00526	A0A024R9B0 O96020
PDB IDs		1LFN
Enriched GO Terms of Interacting Partners?
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