TOB1 and DTL

Number of citations of the paper that reports this interaction (PubMedID 23066029)
10

Data Source:
BioGRID (enzymatic study)

		TOB1	DTL
Description		transducer of ERBB2, 1	denticleless E3 ubiquitin protein ligase homolog
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GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity SH3/SH2 Adaptor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nucleic Acid-templated Transcription	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways			Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Birth weight ( 31043758 27680694) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379)
Interacting Genes		19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 RBX1 TDG TOB1 TP53 UBE2D1 UBE2N
Entrez ID		10140	51514
HPRD ID		09273	17952
Ensembl ID		ENSG00000141232	ENSG00000143476
Uniprot IDs		P50616	B4E0E6 Q9NZJ0
PDB IDs		2D5R 2Z15 5CI8 5CI9	6QC0
Enriched GO Terms of Interacting Partners?
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